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The demographic that shows the highest correlation to developing multidrug-resistant tuberculosis is health care workers. This group is often at a greater risk due to their direct exposure to patients with tuberculosis, including those with drug-resistant strains. Health care workers frequently encounter TB in settings where it is prevalent, such as hospitals or clinics that treat high-risk populations, and may not have adequate protective measures in place, especially in resource-limited environments. The risk of transmission is heightened in these situations, making them particularly vulnerable to contracting multidrug-resistant forms of TB.

While other groups like children under five or elderly individuals may face significant health risks from tuberculosis, they are not necessarily at a higher risk of multidrug resistance compared to the daily exposure experienced by health care workers. Additionally, sports professionals do not engage in situations or environments that would typically expose them to tuberculosis, making them less at risk. Thus, the correlation is strongest for health care workers in relation to developing multidrug-resistant tuberculosis.